Detalhe da pesquisa
1.
Structural Analogs of the GABAkine KRM-II-81 Are Orally Bioavailable Anticonvulsants without Sedation.
J Pharmacol Exp Ther
; 385(1): 50-61, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36746611
2.
Comparative anticonvulsant activity of the GABAkine KRM-II-81 and a deuterated analog.
Drug Dev Res
; 84(3): 527-531, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36748904
3.
Evaluating expert-based habitat suitability information of terrestrial mammals with GPS-tracking data.
Glob Ecol Biogeogr
; 31(8): 1526-1541, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-36247232
4.
Metabolism, pharmacokinetics, and anticonvulsant activity of a deuterated analog of the α2/3-selective GABAkine KRM-II-81.
Biopharm Drug Dispos
; 43(2): 66-75, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-35194800
5.
Catechol estrogens stimulate insulin secretion in pancreatic ß-cells via activation of the transient receptor potential A1 (TRPA1) channel.
J Biol Chem
; 294(8): 2935-2946, 2019 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30587572
6.
The Positive Allosteric Modulator of α2/3-Containing GABAA Receptors, KRM-II-81, Is Active in Pharmaco-Resistant Models of Epilepsy and Reduces Hyperexcitability after Traumatic Brain Injury.
J Pharmacol Exp Ther
; 372(1): 83-94, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31694876
7.
Use of ambiguous detections to improve estimates from species distribution models.
Conserv Biol
; 33(1): 185-195, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30009479
8.
Synthesis of (-)-11-O-Debenzoyltashironin: Neurotrophic Sesquiterpenes Cause Hyperexcitation.
J Am Chem Soc
; 139(28): 9637-9644, 2017 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28644021
9.
Is there a biochemical basis for purinergic P2X3 and P2X4 receptor antagonists to be considered as anti-seizure medications?
Biochem Pharmacol
; 222: 116046, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38341001
10.
Mechanistic and therapeutic relationships of traumatic brain injury and γ-amino-butyric acid (GABA).
Pharmacol Ther
; 256: 108609, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38369062
11.
KRM-II-81 suppresses epileptifom activity across the neural network of cortical tissue from a patient with pharmacoresistant epilepsy.
Heliyon
; 10(1): e23752, 2024 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38223703
12.
New Imidazodiazepine Analogue, 5-(8-Bromo-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-yl)oxazole, Provides a Simplified Synthetic Scheme, High Oral Plasma and Brain Exposures, and Produces Antiseizure Efficacy in Mice, and Antiepileptogenic Activity in Neural Networks in Brain Slices from a Patient with Mesial Temporal Lobe Epilepsy.
ACS Chem Neurosci
; 15(3): 517-526, 2024 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38175916
13.
Mammal responses to global changes in human activity vary by trophic group and landscape.
Nat Ecol Evol
; 8(5): 924-935, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38499871
14.
In Situ Reactive Formation of Mixed Oxides in Additively Manufactured Cobalt Alloy.
Materials (Basel)
; 16(10)2023 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37241334
15.
Transboundary Monitoring of the Wolf Alpine Population over 21 Years and Seven Countries.
Animals (Basel)
; 13(22)2023 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38003168
16.
Wolf genetic diversity compared across Europe using the yardstick method.
Sci Rep
; 13(1): 13727, 2023 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37608038
17.
Behavioral responses of terrestrial mammals to COVID-19 lockdowns.
Science
; 380(6649): 1059-1064, 2023 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37289888
18.
Can GABAkines quiet the noise? The GABAA receptor neurobiology and pharmacology of tinnitus.
Biochem Pharmacol
; 201: 115067, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35504315
19.
GABAkines - Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors.
Pharmacol Ther
; 234: 108035, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34793859
20.
The imidazodiazepine, KRM-II-81: An example of a newly emerging generation of GABAkines for neurological and psychiatric disorders.
Pharmacol Biochem Behav
; 213: 173321, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35041859